Chemical and biosynthetic potential of Penicillium shentong XL-F41

• Ran Zou,
• Xin Li,
• Xiaochen Chen,
• Yue-Wei Guo and
• Baofu Xu

Beilstein J. Org. Chem. 2024, 20, 597–606, doi:10.3762/bjoc.20.52

• all isolated compounds against a panel of microorganisms (Table 4), including Escherichia coli (ATCC 25922), Candida albicans (ATCC 76485), Staphylococcus aureus (ATCC 27154), Pseudomonas fulva (CGMCC 1.15147), and Enterobacter hormaechei (CGMCC 1.10608). The results indicated that compounds 3, 5, 6

• , 7, and 12 were active against Candida albicans. Notably, compound 12 showed particularly promising inhibitory activity against this fungal pathogen. Genome sequencing analysis The genome sequencing yielded 7,118,236 reads with an average read length of 1,858.7 bp. The assembled genome is 34,621,366

A new analog of dihydroxybenzoic acid from Saccharopolyspora sp. KR21-0001

• Rattiya Janthanom,
• Yuta Kikuchi,
• Hiroki Kanto,
• Tomoyasu Hirose,
• Arisu Tahara,
• Takahiro Ishii,
• Arinthip Thamchaipenet and
• Yuki Inahashi

Beilstein J. Org. Chem. 2024, 20, 497–503, doi:10.3762/bjoc.20.44

• -positive bacteria, Kocuria rhizophila ATCC 9341 and Bacillus subtilis ATCC 6633; two strains of Gram-negative bacteria, Escherichia coli Europe NIHJ and Xanthomona campestis pv. oryzae KB 88; and two strains of fungi, Candida albicans ATCC 64548 and Mucor racemosus IFO 4581. All strains were tested by

Synthesis and biological evaluation of Argemone mexicana-inspired antimicrobials

• Jessica Villegas,
• Bryce C. Ball,
• Katelyn M. Shouse,
• Caleb W. VanArragon,
• Ashley N. Wasserman,
• Hannah E. Bhakta,
• Allen G. Oliver,
• Danielle A. Orozco-Nunnelly and
• Jeffrey M. Pruet

Beilstein J. Org. Chem. 2023, 19, 1511–1524, doi:10.3762/bjoc.19.108

• cereus, Bacillus subtilis, Staphylococcus epidermidis, Corynebacterium pseudodiphtheriticum), four Gram-negative bacteria (Escherichia coli, Proteus mirabilis, Enterobacter aerogenes, Enterobacter cloacae), and three fungi (Saccharomyces cerevisiae, Candida albicans, Penicillium chrysogenum). The goal of

Combretastatins D series and analogues: from isolation, synthetic challenges and biological activities

• Jorge de Lima Neto and
• Paulo Henrique Menezes

Beilstein J. Org. Chem. 2023, 19, 399–427, doi:10.3762/bjoc.19.31

• taxol® is the most potent antitumor drug, showing GI50 ranging from pmol to nmol against different types of cancer cell lines [77]. When combretastatins D-2, D-4, and some synthetic intermediates were evaluated against Candida albicans (ATCC 90028), Cryptococcus neoformans (ATCC 90112), Micrococcus

Combining the best of both worlds: radical-based divergent total synthesis

• Kyriaki Gennaiou,
• Antonios Kelesidis,
• Maria Kourgiantaki and
• Alexandros L. Zografos

Beilstein J. Org. Chem. 2023, 19, 1–26, doi:10.3762/bjoc.19.1

• properties, such as potent inhibition of 11-β-hydroxysteroid dehydrogenase type I and inhibition of Candida albicans [48]. Although earlier syntheses have been reported recently for magninoids [50][51], Lou’s group envisioned a divergent plan based on a late-stage bioinspired semipinacol rearrangement

Cyclometalated iridium complexes-catalyzed acceptorless dehydrogenative coupling reaction: construction of quinoline derivatives and evaluation of their antimicrobial activities

• Hongling Shui,
• Yuhong Zhong,
• Renshi Luo,
• Zhanyi Zhang,
• Jiuzhong Huang,
• Ping Yang and
• Nianhua Luo

Beilstein J. Org. Chem. 2022, 18, 1507–1517, doi:10.3762/bjoc.18.159

• compounds was evaluated against Staphylococcus aureus (Gram-positive), Escherichia coli (Gram-negative), and Candida albicans (fungi) mainly by examining the minimum inhibitory concentration (MIC) (Table 4). As shown in Table 4, the compounds 3ab, 3ah, and 3ad showed high antibacterial activities against

• Gram-positive bacteria and Candida albicans. Conclusion In summary, we have developed a new route for the efficient synthesis of quinoxaline and its derivatives with high yield and good chemoselectivity via the ADC reaction of 2-aminobenzyl alcohol and aryl aryl/heteroaryl/alkyl secondary alcohols

Cholyl 1,3,4-oxadiazole hybrid compounds: design, synthesis and antimicrobial assessment

• Anas J. Rasras,
• Mohamed El-Naggar,
• Nesreen A. Safwat and
• Raed A. Al-Qawasmeh

Beilstein J. Org. Chem. 2022, 18, 631–638, doi:10.3762/bjoc.18.63

• biological activities such as anti-COVID-19 [5], anticancer [6][7][8], antibacterial activity against Staphylococcus aureus and Bacillus subtilis [9][10], antifungal agents against Candida albicans and phytopathogenic fungi [11][12], and antiproliferative against different cell lines (e.g., PC3, HCT-116, and

• against the pathogenic fungal strains Aspergillus fumigatus and Candida albicans. The sensitivity of the organisms was assayed against the activity of tested compounds solutions (at 10 mg/mL concentration) using a modified agar well diffusion method with determination of the inhibition zone diameter in mm

• , 4p and 4c, respectively. Besides, the order of antifungal activity against the pathogenic yeast Candida albicans was 4g, 4i, 4q, 4j, 4o, 4p, 4m, 4k, 4s, 4t, 4n, 4v, 4d, 4e, 4h, 4l, 4c and 4r, respectively (Table 1). Likewise, no antimicrobial activities could be detected for compound 4f under these

Tenacibactins K–M, cytotoxic siderophores from a coral-associated gliding bacterium of the genus Tenacibaculum

• Yasuhiro Igarashi,
• Yiwei Ge,
• Tao Zhou,
• Amit Raj Sharma,
• Enjuro Harunari,
• Naoya Oku and
• Agus Trianto

Beilstein J. Org. Chem. 2022, 18, 110–119, doi:10.3762/bjoc.18.12

• Antimicrobial activity was examined as previously reported [41]. Kocuria rhizophila ATCC9341, Staphylococcus aureus FDA209P JC-1, Ralstonia solanacearum SUPP1541, Escherichia coli NIHJ JC-2, Rhizobium radiobacter NBRC14554, and Candida albicans NBRC0197 were used as indication strains. Cytotoxicity against 3Y1

Unsaturated fatty acids and a prenylated tryptophan derivative from a rare actinomycete of the genus Couchioplanes

• Shun Saito,
• Kanji Indo,
• Naoya Oku,
• Hisayuki Komaki,
• Masashi Kawasaki and
• Yasuhiro Igarashi

Beilstein J. Org. Chem. 2021, 17, 2939–2949, doi:10.3762/bjoc.17.203

• , Rhizobium radiobacter and Escherichia coli, or a yeast Candida albicans (MIC > 100 μg/mL). Compounds 1–5 were marginally active against Kocuria rhizophila (MIC = 100 μg/mL). Conclusion In this study, five unsaturated fatty acids (1–5) and one prenylated tryptophan derivative (6) were isolated as new natural

Biological properties and conformational studies of amphiphilic Pd(II) and Ni(II) complexes bearing functionalized aroylaminocarbo-N-thioylpyrrolinate units

• Samet Poyraz,
• Samet Belveren,
• Sabriye Aydınoğlu,
• Mahmut Ulger,
• Abel de Cózar,
• Maria de Gracia Retamosa,
• Jose M. Sansano and
• H. Ali Döndaş

Beilstein J. Org. Chem. 2021, 17, 2812–2821, doi:10.3762/bjoc.17.192

• . Antifungal activity of the novel compounds was also evaluated against Candida albicans, Candida tropicalis and Candida glabrata strains. Antibacterial and antituberculosis (TB) activities From the observed data (Table 1) it can be seen that the tested compounds showed moderate antibacterial activity, in the

• supplement at the same solutions. Microdilution broth method [31][32] was used to determine the MIC values of the target compounds against to Candida albicans (ATCC 14053), C. tropicalis (ATCC 1369) and C. glabrata (ATCC 15126) standard strains (which were provided from Refik Saydam Hıfzıssıhha Institute in

Nomimicins B–D, new tetronate-class polyketides from a marine-derived actinomycete of the genus Actinomadura

• Zhiwei Zhang,
• Tao Zhou,
• Taehui Yang,
• Keisuke Fukaya,
• Enjuro Harunari,
• Shun Saito,
• Katsuhisa Yamada,
• Chiaki Imada,
• Daisuke Urabe and
• Yasuhiro Igarashi

Beilstein J. Org. Chem. 2021, 17, 2194–2202, doi:10.3762/bjoc.17.141

• antimicrobial activity against Kocuria rhizopila with a MIC value of 6.5 μg/mL and 1 and 2 were also active against Bacillus subtilis with a MIC value of 12.5 μg/mL. Compounds 1–3 were inactive against Staphylococcus aureus, Ralstonia solanacearum, Rhizobium radiobacter, and Candida albicans. In addition, 1 and

Chemical approaches to discover the full potential of peptide nucleic acids in biomedical applications

• Nikita Brodyagin,
• Martins Katkevics,
• Venubabu Kotikam,
• Christopher A. Ryan and
• Eriks Rozners

Beilstein J. Org. Chem. 2021, 17, 1641–1688, doi:10.3762/bjoc.17.116

Double-headed nucleosides: Synthesis and applications

• Vineet Verma,
• Jyotirmoy Maity,
• Vipin K. Maikhuri,
• Ritika Sharma,
• Himal K. Ganguly and
• Ashok K. Prasad

Beilstein J. Org. Chem. 2021, 17, 1392–1439, doi:10.3762/bjoc.17.98

Nocarimidazoles C and D, antimicrobial alkanoylimidazoles from a coral-derived actinomycete Kocuria sp.: application of ¹J_C,H coupling constants for the unequivocal determination of substituted imidazoles and stereochemical diversity of anteisoalkyl chains in microbial metabolites

• Md. Rokon Ul Karim,
• Enjuro Harunari,
• Amit Raj Sharma,
• Naoya Oku,
• Kazuaki Akasaka,
• Daisuke Urabe,
• Mada Triandala Sibero and
• Yasuhiro Igarashi

Beilstein J. Org. Chem. 2020, 16, 2719–2727, doi:10.3762/bjoc.16.222

• the same as those for 1 (Table 1). The antimicrobial activity of 1–4 was tested against Gram-positive bacteria Kocuria rhizophila and Staphylococcus aureus, Gram-negative bacteria Escherichia coli and Rhizobium radiobacter, a yeast Candida albicans, and two fungi Glomerella cingulata and Trichophyton

Synthesis of 1,4-benzothiazinones from acylpyruvic acids or furan-2,3-diones and o-aminothiophenol

• Ekaterina E. Stepanova,
• Maksim V. Dmitriev and
• Andrey N. Maslivets

Beilstein J. Org. Chem. 2020, 16, 2322–2331, doi:10.3762/bjoc.16.193

• (detailed data on biological assays is given in Supporting Information File 1). Unfortunately, we found that tested BTAs 3 did not show any significant antimicrobial activity (against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Candida

• albicans, Cryptococcus neoformans var. grubii, Mycobacterium tuberculosis) in vitro. Acute toxicity of BTA 3a in mice was determined to be higher than 1000 mg/kg, which means that BTA 3a can be considered as low toxic. Conclusion In conclusion, we developed two interchangeable approaches to enaminones

4-Hydroxy-3-methyl-2(1H)-quinolone, originally discovered from a Brassicaceae plant, produced by a soil bacterium of the genus Burkholderia sp.: determination of a preferred tautomer and antioxidant activity

• Dandan Li,
• Naoya Oku,
• Yukiko Shinozaki,
• Yoichi Kurokawa and
• Yasuhiro Igarashi

Beilstein J. Org. Chem. 2020, 16, 1489–1494, doi:10.3762/bjoc.16.124

• aureus FDA209P JC-1 (Gram-positive bacterium), Rhizobium radiobacter NBRC14554, Ralstonia solanacearum SUPP1541, Tenacibaculum maritimum NBRC16015 (Gram-negative bacteria), Candida albicans NBRC0197, and Saccharomyces cerevisiae S100 (yeasts). Oxidative burst, which is a transient production of massive

A cyclopeptide and three oligomycin-class polyketides produced by an underexplored actinomycete of the genus Pseudosporangium

• Shun Saito,
• Kota Atsumi,
• Tao Zhou,
• Keisuke Fukaya,
• Daisuke Urabe,
• Naoya Oku,
• Md. Rokon Ul Karim,
• Hisayuki Komaki and
• Yasuhiro Igarashi

Beilstein J. Org. Chem. 2020, 16, 1100–1110, doi:10.3762/bjoc.16.97

• inactive against Staphylococcus aureus, Escherichia coli, Rhizobium radiobacter, and Candida albicans. The antimicrobial potency of 2 and 3 were similar, implying that the acyl side chain at C13 of compound 2 had no influence on the activity. In addition, compounds 1–4 showed moderate cytotoxicity against

Two antibacterial and PPARα/γ-agonistic unsaturated keto fatty acids from a coral-associated actinomycete of the genus Micrococcus

• Amit Raj Sharma,
• Enjuro Harunari,
• Naoya Oku,
• Nobuyasu Matsuura,
• Agus Trianto and
• Yasuhiro Igarashi

Beilstein J. Org. Chem. 2020, 16, 297–304, doi:10.3762/bjoc.16.29

• interesting contrast. No appreciable antimicrobial activity was observed for both compounds against bacterial strains of Micrococcus luteus ATCC9341, Staphylococcus aureus FDA209P JC-1, and Escherichia coli NIHJ JC-2 and yeast strains of Candida albicans NBRC0197 and Saccharomyces cerevisiae S100, nor

• bacteria, Micrococcus luteus ATCC9341, Staphylococcus aureus FDA209P JC-1, Rhizobium radiobacter NBRC14554, Escherichia coli NIHJ JC-2, Tenacibaculum maritimum NBRC16015, and two yeasts, Candida albicans NBRC0197 and Saccharomyces cerevisiae S100, as indication strains. Mueller–Hinton Broth (Difco

Skeletocutins M–Q: biologically active compounds from the fruiting bodies of the basidiomycete Skeletocutis sp. collected in Africa

• Tian Cheng,
• Clara Chepkirui,
• Cony Decock,
• Josphat C. Matasyoh and
• Marc Stadler

Beilstein J. Org. Chem. 2019, 15, 2782–2789, doi:10.3762/bjoc.15.270

• coli (E. coli) DSM498, Chromobacterium violaceum (C. violaceum) DSM30191, and Pseudomonas aeruginosa (P. aeruginosa) PA14. Moreover, the filamentous fungus Mucor plumbeus (M. plumbeus) MUCL49355 and the yeasts Candida tenuis (C. tenuis) MUCL29892, Pichia anomala (P. anomala) DSM6766, and Candida

• albicans (C. albicans) DSM1665 were applied. The assays were conducted in 96-well plates and Mueller–Hinton Broth (MHB) for bacteria, or yeast, malt, and gluocse (YMG) medium for filamentous fungus and yeasts. Cytotoxicity assay In vitro cytotoxicity, using IC50 values as a measure, was evaluated against

Nanangenines: drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensis

• Heather J. Lacey,
• Cameron L. M. Gilchrist,
• Andrew Crombie,
• John A. Kalaitzis,
• Daniel Vuong,
• Peter J. Rutledge,
• Peter Turner,
• John I. Pitt,
• Ernest Lacey,
• Yit-Heng Chooi and
• Andrew M. Piggott

Beilstein J. Org. Chem. 2019, 15, 2631–2643, doi:10.3762/bjoc.15.256

• three human cell lines. None of the compounds tested showed any activity up to 100 μg mL−1 against the Gram-negative bacterium Escherichia coli (ATCC 25922), the fungus Candida albicans (ATCC 10231) or the plant Eragrostis tef (teff). Proposed biosynthesis and gene cluster The biosynthesis of drimane

Isolation and biosynthesis of an unsaturated fatty acid with unusual methylation pattern from a coral-associated bacterium Microbulbifer sp.

• Amit Raj Sharma,
• Enjuro Harunari,
• Tao Zhou,
• Agus Trianto and
• Yasuhiro Igarashi

Beilstein J. Org. Chem. 2019, 15, 2327–2332, doi:10.3762/bjoc.15.225

• luteus ATCC9341, Bacillus subtilis ATCC6633, Escherichia coli NIHJ JC-2, Ralstonia solanacearum SUPP1541, Rhizobium radiobacter NBRC14554, and Candida albicans NBRC0197 (MIC > 100 μg/mL) but weakly active against Saccharomyces cerevisiae S100 (MIC 100 μg/mL). Conclusion In summary, chemical investigation

• microtiter plates against six bacteria, Bacillus subtilis ATCC6633, Micrococcus luteus ATCC9341, Staphylococcus aureus FDA209P JC-1, Ralstonia solanacearum SUPP1541, Rhizobium radiobacter NBRC14554, Escherichia coli NIHJ JC-2, and two yeasts Candida albicans NBRC0197 and Saccharomyces cerevisiae S100 as

Metal-free C–H mercaptalization of benzothiazoles and benzoxazoles using 1,3-propanedithiol as thiol source

• Yan Xiao,
• Bing Jing,
• Xiaoxia Liu,
• Hongyu Xue and
• Yajun Liu

Beilstein J. Org. Chem. 2019, 15, 279–284, doi:10.3762/bjoc.15.24

• activity against Candida albicans and Candida tropicalis [8] and 2-mercapto-1,3-benzothiol and its derivatives exhibit inhibitory effects against thyroid peroxidase [9]. (Hetero)aryl thiols are often prepared from the corresponding halides through direct nucleophilic substitution [10][11][12] or metal

Lectins of Mycobacterium tuberculosis – rarely studied proteins

• Katharina Kolbe,
• Sri Kumar Veleti,
• Norbert Reiling and
• Thisbe K. Lindhorst

Beilstein J. Org. Chem. 2019, 15, 1–15, doi:10.3762/bjoc.15.1

• products of Rv1753 and Rv2082 were reported to have 27% and 25% amino acid sequence similarity to the ALS1 gene from Candida albicans, which encodes the candida adhesin [78]. This lectin is cell surface-localized and mediates adherence of the fungus to endothelial and epithelial cells [86][87]. Fucose

Lanyamycin, a macrolide antibiotic from Sorangium cellulosum, strain Soce 481 (Myxobacteria)

• Lucky S. Mulwa,
• Rolf Jansen,
• Dimas F. Praditya,
• Kathrin I. Mohr,
• Patrick W. Okanya,
• Joachim Wink,
• Eike Steinmann and
• Marc Stadler

Beilstein J. Org. Chem. 2018, 14, 1554–1562, doi:10.3762/bjoc.14.132

• -HPLC fractionating and peak-activity correlation we further noted at tR = 18–25 min an inhibition overlap of Micrococcus luteus and Candida albicans, which correlated with some prominent peaks with unique HPLC-DAD-MS characteristics attracting our interest. Consequently, the fermentation process was

Two new 2-alkylquinolones, inhibitory to the fish skin ulcer pathogen Tenacibaculum maritimum, produced by a rhizobacterium of the genus Burkholderia sp.

• Dandan Li,
• Naoya Oku,
• Atsumi Hasada,
• Masafumi Shimizu and
• Yasuhiro Igarashi

Beilstein J. Org. Chem. 2018, 14, 1446–1451, doi:10.3762/bjoc.14.122

• NBRC16015, Trichophyton rubrum NBRC5467, Candida albicans NBRC0197 (human opportunistic pathogen), R. oryzae NBRC4705, Glomerella cingulata NBRC5907 (pathogen of anthracnose), Ralstonia solanacearum SUPP1541 (pathogen of bacterial wilt of Solanaceous plants), Rhizobium radiobacter NBRC14554 (pathogen of